Publications and Patents

[43] Bergonzi C, Schwab M, Elias M. Purification, characterization, crystallization and crystallographic analysis of the quorum quenching lactonase from Geobacillus caldoxylosilyticusActa Cryst F. accepted. PMID: to come
[42] Bzdrenga J, Daudé D, Jacquet P, Remy, B, Plener L, Elias M, Chabrière E. Biotechnological applications of quorum quenching enzymes. Chem Biol Interact. PMID: 27223408

[41] Jacquet P, Daudé D, Bzdrenga J, Masson P, Elias M, Chabrière E. Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes. Environ Sci Pollut Res Int. PMID: 26832878


[40] Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS. Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder. J Mol Biol. 427:2396-409. PMID: 26004540

[39] Hiblot J, Bzdrenga J, Champion C, Chabriere E, Elias M. Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia. Scientific Reports. 2015; 5:8372. PMID: 25670483


[38] Hraiech S, Hiblot J, Lafleur J, Lepidi H, Papazian L, Rolain JM, Raoult D, Elias M, Silby MW, Bzdrenga J, Bregeon F, Chabriere E. Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia. PLoS One. 2014; 9(10):e107125. PMID: 25350373

[37] Gonzalez D, Richez M, Bergonzi C, Chabriere E, Elias M.. Crystal structure of the phosphate-binding protein (PBP-1) of an ABC-type phosphate transporter from Clostridium perfringens. Scientific Reports, 4:6636. PMID: 25338617

[36] Gonzalez D, Elias M, Chabrière E. The DING Family of Phosphate Binding Proteins in Inflammatory Diseases. Adv Exp Med Biol. 2014;824:27-32. PMID: 25038991

[35] Bzdrenga J, Hiblot J, Gotthard G, Champion C, Elias M#, Chabriere E#. SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase. BMC Res Notes. (2014);7:333. PMID: 24894602

[34] Alcolombri U, Elias M, Vardi A, Tawfik DS. “Ambiguous evidence for assigning DddQ as a dimethylsulfoniopropionate lyase and oceanic dimethylsulfide producer”. PNAS. (2014) 111:E2078-9. PMID: 24760823

[33] Gonzalez D, Hiblot J, Darbinian N, Miller J, Gotthard G, Amini S, Chabriere E,Elias M.   “Ancestral mutations as a tool for solubilizing proteins: the case of a hydrophobic phosphate-binding protein” (2014) FEBS open bio, 4:121-7. PMID: 24490136

[32] Elias M, Wieczorek G, Rosenne S, Tawfik DS. “The Universality of Enzymatic Rate-Temperature Dependency” (2014) Trends in Biochemical Sciences, 39;1-7. PMID: 24315123


[31] Gotthard G, Hiblot J, Gonzalez D, Elias M# and Chabriere E#. “Structural and enzymatic characterization of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes”, (2013) PloS One, 8:e77995.PMID: 24223749

[30] Hiblot J, Gotthard G, Champion C, Eric Chabriere and Mikael Elias#.“Crystallization and preliminary X-ray diffraction analysis of the lactonase VmoLac from Vulcanisaeta moutnovskia”, (2013) Acta Cryst F, 69:1235-8. PMID: 24192357

[29] Djeghader A,  Gotthard G,  Suh A,  Gonzalez D,  Scott K, Chabriere E and Elias M. “Crystallization and preliminary X-ray diffraction analysis of a high affinity phosphate-binding protein endowed with phosphatase activity from Pseudomonas aeruginosa PAO1”, (2013) Acta Cryst F, 69:1143-1146. PMID: 24100568

[28] Hiblot J, Gotthard G, Chabriere E# and Elias M#. “Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox”, (2013) PloS One, 8: e7527. PMID: 24086491

[27] Elias M, Liebschner D, Koepke J, Lecomte C, Guillot B, Jelsch C and Chabriere E. “Hydrogen atoms in protein structures: high-resolution X-ray diffraction structure of the DFPase”, (2013) BMC Research notes, 6:308. PMID: 23915572                                        

[26] Dellus-Gur E, Toth-Petroczy A, Elias M#, Tawfik DS#. “What makes a protein fold amenable to functional innovation? Fold polarity and stability tradeoffs”, (2013) JMB, 425:2609-21. PMID: 23542341

[25] Djeghader A, Gotthard G, Suh A, Gonzalez D, Scott K, Elias M, Chabriere E.“Crystallization and preliminary X-ray diffraction analysis of a DING protein from Pseudomonas aeruginosa PA14”, (2013) Acta Cryst F, 69:425-9. PMID: 23545651

[24] Ben-David M; Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS. “Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme”, (2013) JMB, 425:1028-38. PMID: 23318950


[23] Gotthard G, Hiblot J, Gonzalez D, Chabriere E, Elias M. “Crystallization and preliminary X-ray diffraction analysis of the organophosphorus hydrolase OPHC2 from Pseudomonas pseudoalcaligenes”, (2012) Acta Cryst F, 69:73-6. PMID: 23295492

[22] Hiblot H, Gotthard G, Chabriere E, Elias M. “Characterisation of the organophosphate hydrolase catalytic activity of SsoPox”, (2012) Scientific Reports, 2:779. PMID: 23139857

[21] Hiblot J, Gotthard G, Chabriere E, Elias M.  “Structural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus”, (2012) Plos One, 7(10):e47028. PMID: 23071703

[20] Elias M, Wellner A, Goldin-Azulay K, Chabriere E,  Vorholt JA, Erb TJ & Tawfik DS. “The molecular basis of phosphate discrimination in arsenate rich environments”, (2012) Nature, 491(7422):134-7. PMID: 23034649. See also editorial: “Arsenic-life’ bacterium prefers phosphorus after all”, (2012) Nature, doi: 10.1038/nature.2012.11520. Daniel Cressey.

Ranked 41/100 major scientific discoveries in 2012. see the Discover Magazine ranking

News: The Scientist; Sciencenews,org;;; Scientific american;; discovermagazine

[19] Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS. “Catalytic versatility and backups in enzyme active sites: The case of serum paraoxonase 1”, (2012) JMB, 418:181-96. PMID: 22387469

[18] Djeghader A; Aragonès G; Darbinian N; Elias M; Gonzalez D; García-Heredia A; Beltrán-Debón R; Kaminski R; Gotthard G; Hiblot J; Rull A; Rohr O; Schwartz C; Alonso-Villaverde C; Joven J; Camps J; Chabriere E. “The Level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies”, (2012), PloS One, 7:e33062. PMID: 22427948

[17] Elias M & Tawfik DS. “Divergence and Convergence in Enzyme Evolution: The Parallel Evolution of Paraoxonases from Quorum Quenching Lactonases”, (2012) J Biol Chem, 287:11-20. PMID: 22069329

[4] Elias M, Hiblot J, Raoult D & Chabriere E; Sulfolobal Phosphotriesterase-Like (PLL) Lactonases activity having enhanced properties and the uses thereof. EP 13305483, 12/04/13.

[3] Elias M, Hiblot J, Raoult D & Chabriere E; EP 13306109, 31/07/13. Vulcanalial Phosphotriesterase-Like (PLL) Lactonases activity having enhanced properties and the uses thereof.

[2] Elias M, Chabriere E. Mutated hyperthermophilic phosphotriesterases and uses thereof, W2008,145,865.

[1] Elias M, Chabriere E, Rohr O, Schwartz C. Novel antiviral agent, WO 2010,100,381.

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