top of page


[74] Corbella M, Bravo J, Demkiv AO, Calixto AR, Sompiyachoke K, Bergonzi C, Elias MH, Kamerlin SCL. Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases. BiorXiv
[73] Sikdar R, Beauclaire MV, Lima BP, Herzberg MC, Elias MH. N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque. Biorxiv.
[72] Tassoulas LJ, Rankin, JA, Elias MH, Wackett, LP. Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. PNAS, 121, e2312652121. PMID: 38408229
[71] Elias MH, Sompiyachoke K, Fernández, FM, Kamerlin, SCL. The ineligibility barrier for international researchers in US academia. EMBO Rep, PMID: 38263328
[70] Sompiyachoke K, Elias M. Engineering Quorum Quenching Acylases with Improved Kinetic and Biochemical Properties. Protein Science. PMID: 38520282
[69] Jacquet P, Billot R, Shimon A, Hoekstra N, Bergonzi C, Jenks A, Chabrière E, Daudé D. Elias M. Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity. Biorxiv. JACS Au, 4(5):1941-1953. PMID: 38818068
[68] Crone KK, Jomori T, Miller FS, Gralnick J, Elias M, Freeman MF. RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-N-methylated peptide natural product. RSC Chemical Biology, accepted.
[67] M Campos, Q Zhang, JJ Acuña, JI Rilling, T Ruiz, E Carrazana, C Reyno, A Hollenback, K Gray, DP Jaisi, A Ogram, J Bai, L Zhang, R Xiao, M Elias, MJ Sadowsky, J Hu, MA Jorquera. Structure and Functional Properties of Bacterial Communities in Surface Sediments of the Recently Declared Nutrient-Saturated Lake Villarrica in Southern Chile. Microbial ecology, 1-21. PMID: 36752910
[66] Huang S, Bergonzi C, Smith S, Hicks R, Elias M. Field testing of an enzymatic quorum quencher coating additive to reduce biocorrosion of steel. Microbiology Spectrum, PMID: 37668433
[65] Billot R, Plener L, Grizard D, Elias M, Chabriere E, Daude D. Applying molecular and phenotypic screening assays to identify efficient quorum quenching lactonases. Enzyme and Microbial Technology, 110092. PMID: 35797848.
[64] Sikdar R, Elias M. Evidence for complex interplay between quorum sensing and antibiotic resistance in Pseudomonas aeruginosa. Microbiology Spectrum, e0126922. PMID: 36314960.
[63] Miller FS, Crone KK, Jensen MR, Shaw S, Harcombe WR, Elias M, Freeman MF. Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis. Nat. Commun., 12(1):5355. PMID: 34504067.
[00] Elias M, Fraser JS, Kamerlin SCL, Patrick WM,  Jackson CJ. Dan Salah Tawfik (1955-2021)—A giant of protein evolution. Embo Rep, 22:e53256. doi: 10.15252/embr.202153256.
[62] Tassoulas L, Elias M, Wackett LP. Discovery of an ultra-specific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway. J Biol Chem, 296:100055. PMID: 33172891.
[61] Billot R, Plener L, Jacquet P, Elias M, Chabrière E, Daudé D. Engineering Acyl-Homoserine Lactone-Interfering Enzymes Towards Bacterial Control. J Biol Chem, accepted. PMID: 32690609.
[60] Sikdar and Elias. Quorum quenching enzymes and their effects on virulence, biofilm and microbiomes: a review of recent advances. Expert Review of Anti-infective Therapy, Aug 4;1-13. PMID: 32749905.
[59] Rémy, Plener, Decloquement, Armstrong, Elias, Daudé, Chabrière. Lactonase Specificity Is Key to Quorum Quenching in Pseudomonas aeruginosa. Frontiers in Microbiology, 11:762. PMID: 32390993.
[58] Mahan K, Martinmaki R, Larus I, Sikdar R, Dunitz J, Elias M. Effects of Signal Disruption Depends on the Substrate Preference of the Lactonase. Frontiers in Microbiology, 10: 3003. PMID: 31993034.
[57] Schwab M, Bergonzi C,  Sakkos J, Staley C, Zhang Q, Sadowsky M, Aksan A, Elias M. Signal Disruption Leads to Changes in Bacterial Community Population. Frontiers in Microbiology, 10:611. PMID: 30984139.
[56] Huang S, Bergonzi C, Schwab M,  Elias M, Hicks R. Evaluation of biological and enzymatic quorum quencher coating additives to reduce biocorrosion of steel. Plos One. 14:e0217059. PMID: 31095643.
[55] Bergonzi C,  Schwab M, Naik T,  Elias M. The Structural Determinants Accounting for the Broad Substrate Specificity of the Quorum Quenching Lactonase GcL. ChemBioChem. 20:14; 1848-1855. PMID: 30864300. Very Important Paper (VIP)
[54] Bergonzi C,  Schwab M, Naik T, Daude D, Chabriere E,  Elias M. Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties. Scientific Reports. 8:11262. PMID: 30050039.
[53] Remy B,  Mion S, Plener L,  Elias M, Chabriere E, Daude D. Interference in Bacterial Quorum Sensing: a Biopharmaceutical Perspective. Frontiers in Pharmacology. 9:203. PMID: 29563876.
[52] Haywood J,  Schmidberger JW, James AM, Nonis SG, Sukhoverkov KV, Elias M, Bond CS, Mylne JS. Structural basis of ribosomal peptide macrocyclization in plants. Elife. 7:16745. PMID: 29384475

[51] Jacquet P,  Hiblot J, Daude D, Bergonzi C, Gotthard G, Armstrong N, Chabriere E, Elias M. Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase. Scientific Reports. 7:16745. PMID: 29196634
[50] Purg. M,  Elias M, Kamerlin SCL. Similar Active Sites and Mechanisms Do Not Lead to Cross-Promiscuity in Organophosphate Hydrolysis: Implications for Biotherapeutic Engineering. JACS. PMID: 29113434
[49] Bergonzi C, Schwab M, Chabriere E, Elias M. Purification, kinetic characterization, crystallization and crystallographic analysis of the quorum quenching lactonase from Alicyclobacter acidoterrestrisActa Cryst F. 73:476-480. PMID: 28777091
[48] Pegos V, Hey L, LaMirande J, Pfeffer R, Lipsh R, Amitay M, Gonzalez D, Elias M. Purification, characterization, crystallization and S-SAD phasing of the Phosphate-Binding Protein from Polaromonas JS666. Acta Cryst F . F73, 342-346. PMID: 28580922
[47] Bera A, Aukema K, Elias M, Wackett L. Structure of the Cyanuric Acid Hydrolase TrzD Reveals Product Exit Channel. Scientific Reports . PMID: 28345631
[46] Guendouze A, Plener L, Bzdrenga J, Jacquet P, Remy B, Elias M, Lavigne J-P, Daudé D, Chabrière E. Effect of quorum quenching lactonase in clinical isolates of Pseudomonas aeruginosa and comparison with quorum sensing inhibitors. Frontiers in Microbiology . PMID: 28261183
[45] Remy B, Plener L, Poirier L, Elias M, Daudé D, Chabrière E. Harnessing hyperthermostable enzyme for biotechnological applications. Scientific Reports.PMID: 27876889
[44] Remy B, Plener L, Elias M, Daudé D, Chabrière E. Enzymes for disrupting bacterial communication, an alternative to antibiotics?. Ann Pharm Fr. PMID: 27475310
[43] Bergonzi C, Schwab M, Elias M. Purification, characterization, crystallization and crystallographic analysis of the quorum quenching lactonase from Geobacillus caldoxylosilyticusActa Cryst F. 72:681-6. PMID: 27599858
[42] Bzdrenga J, Daudé D, Jacquet P, Remy, B, Plener L, Elias M, Chabrière E. Biotechnological applications of quorum quenching enzymes. Chem Biol Interact. S0009-2797(16)30198-3. PMID: 27223408

[41] Jacquet P, Daudé D, Bzdrenga J, Masson P, Elias M, Chabrière E. Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes. Environ Sci Pollut Res Int. 23:8200-18. PMID: 26832878


[40] Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS. Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder. J Mol Biol. 427:2396-409. PMID: 26004540

[39] Hiblot J, Bzdrenga J, Champion C, Chabriere E, Elias M. Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia. Scientific Reports. 2015; 5:8372. PMID: 25670483


[38] Hraiech S, Hiblot J, Lafleur J, Lepidi H, Papazian L, Rolain JM, Raoult D, Elias M, Silby MW, Bzdrenga J, Bregeon F, Chabriere E. Inhaled Lactonase Reduces Pseudomonas aeruginosa Quorum Sensing and Mortality in Rat Pneumonia. PLoS One. 2014; 9(10):e107125. PMID: 25350373

[37] Gonzalez D, Richez M, Bergonzi C, Chabriere E, Elias M.. Crystal structure of the phosphate-binding protein (PBP-1) of an ABC-type phosphate transporter from Clostridium perfringens. Scientific Reports, 4:6636. PMID: 25338617

[36] Gonzalez D, Elias M, Chabrière E. The DING Family of Phosphate Binding Proteins in Inflammatory Diseases. Adv Exp Med Biol. 2014;824:27-32. PMID: 25038991

[35] Bzdrenga J, Hiblot J, Gotthard G, Champion C, Elias M#, Chabriere E#. SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase. BMC Res Notes. (2014);7:333. PMID: 24894602

[34] Alcolombri U, Elias M, Vardi A, Tawfik DS. “Ambiguous evidence for assigning DddQ as a dimethylsulfoniopropionate lyase and oceanic dimethylsulfide producer”. PNAS. (2014) 111:E2078-9. PMID: 24760823

[33] Gonzalez D, Hiblot J, Darbinian N, Miller J, Gotthard G, Amini S, Chabriere E, Elias M.   “Ancestral mutations as a tool for solubilizing proteins: the case of a hydrophobic phosphate-binding protein” (2014) FEBS open bio, 4:121-7. PMID: 24490136

[32] Elias M, Wieczorek G, Rosenne S, Tawfik DS. “The Universality of Enzymatic Rate-Temperature Dependency” (2014) Trends in Biochemical Sciences, 39;1-7. PMID: 24315123


[31] Gotthard G, Hiblot J, Gonzalez D, Elias M# and Chabriere E#. “Structural and enzymatic characterization of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes”, (2013) PloS One, 8:e77995.PMID: 24223749

[30] Hiblot J, Gotthard G, Champion C, Eric Chabriere and Mikael Elias#.“Crystallization and preliminary X-ray diffraction analysis of the lactonase VmoLac from Vulcanisaeta moutnovskia”, (2013) Acta Cryst F, 69:1235-8. PMID: 24192357

[29] Djeghader A,  Gotthard G,  Suh A,  Gonzalez D,  Scott K, Chabriere E and Elias M. “Crystallization and preliminary X-ray diffraction analysis of a high affinity phosphate-binding protein endowed with phosphatase activity from Pseudomonas aeruginosa PAO1”, (2013) Acta Cryst F, 69:1143-1146. PMID: 24100568

[28] Hiblot J, Gotthard G, Elias M# and Chabriere#. “Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox”, (2013) PloS One, 8: e7527. PMID: 24086491

[27] Elias M, Liebschner D, Koepke J, Lecomte C, Guillot B, Jelsch C and Chabriere E. “Hydrogen atoms in protein structures: high-resolution X-ray diffraction structure of the DFPase”, (2013) BMC Research notes, 6:308. PMID: 23915572                                        

[26] Dellus-Gur E, Toth-Petroczy A, Elias M#, Tawfik DS#. “What makes a protein fold amenable to functional innovation? Fold polarity and stability tradeoffs”, (2013) JMB, 425:2609-21. PMID: 23542341

[25] Djeghader A, Gotthard G, Suh A, Gonzalez D, Scott K, Elias M, Chabriere E.“Crystallization and preliminary X-ray diffraction analysis of a DING protein from Pseudomonas aeruginosa PA14”, (2013) Acta Cryst F, 69:425-9. PMID: 23545651

[24] Ben-David M; Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS. “Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme”, (2013) JMB, 425:1028-38. PMID: 23318950


[23] Gotthard G, Hiblot J, Gonzalez D, Chabriere E, Elias M. “Crystallization and preliminary X-ray diffraction analysis of the organophosphorus hydrolase OPHC2 from Pseudomonas pseudoalcaligenes”, (2012) Acta Cryst F, 69:73-6. PMID: 23295492

[22] Hiblot H, Gotthard G, Chabriere E, Elias M. “Characterisation of the organophosphate hydrolase catalytic activity of SsoPox”, (2012) Scientific Reports, 2:779. PMID: 23139857

[21] Hiblot J, Gotthard G, Chabriere E, Elias M.  “Structural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus”, (2012) Plos One, 7(10):e47028. PMID: 23071703

[20] Elias M, Wellner A, Goldin-Azulay K, Chabriere E,  Vorholt JA, Erb TJ & Tawfik DS. “The molecular basis of phosphate discrimination in arsenate rich environments”, (2012) Nature, 491(7422):134-7. PMID: 23034649.

See also editorial: “Arsenic-life’ bacterium prefers phosphorus after all”, (2012) Nature, doi: 10.1038/nature.2012.11520. Daniel Cressey.

See the Discover Magazine

News: The Scientist; Sciencenews,org;;; Scientific american;; discovermagazine

[19] Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS. “Catalytic versatility and backups in enzyme active sites: The case of serum paraoxonase 1”, (2012) JMB, 418:181-96. PMID: 22387469

[18] Djeghader A; Aragonès G; Darbinian N; Elias M; Gonzalez D; García-Heredia A; Beltrán-Debón R; Kaminski R; Gotthard G; Hiblot J; Rull A; Rohr O; Schwartz C; Alonso-Villaverde C; Joven J; Camps J; Chabriere E. “The Level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies”, (2012), PloS One, 7:e33062. PMID: 22427948

[17] Elias M & Tawfik DS. “Divergence and Convergence in Enzyme Evolution: The Parallel Evolution of Paraoxonases from Quorum Quenching Lactonases”, (2012) J Biol Chem, 287:11-20. PMID: 22069329

[16] Chérier T*, Elias M*, Jeudy A, Le Douce V, Hallay H. Masson P, Janossy A., Candolfi E, Rohr O, Schwartz C, Chabriere E. “Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication”, (2011) Virology Journal, 8:352. PMID: 21762475

[15] Alcolombri U, Elias M#, Tawfik DS#. “Directed evolution of sulfotransferases and paraoxonases by ancestral libraries” (2011), JMB, 411;837-53. PMID: 21723874

[14] Gotthard G, Hiblot J, Elias M, Chabrière E. “Crystallization and preliminary X-ray diffraction analysis of the hyperthermophilic Sulfolobus islandicus lactonase” (2011), Acta Cryst F67, 354-357. PMID: 21393842

[13] Elias M, Liebschner D, Gotthard G, Chabriere E. “Structural insights and ab initio sequencing within the DING proteins family” (2011), Review, part of the special issue for ISDSB2010, Journal of Synchrotron Radiation, 18:45-9. PMID: 21169690


[12] Collombet JM, Elias M, Gotthard G, Four E, Renault F, Joffre A, Baubichon D, Rochu D, Chabriere E. “Eukaryotic DING proteins are endogenous: an immunohistological study in mouse tissues” (2010), PloS One, 5(2):e9099. PMID: 20161715

[11] Renault F, Carus T, Cléry-Barraud C, Elias M, Chabrière E, Masson P, Rochu D “Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1)” (2010), J Chrom B, 878:1346-55.. PMID: 19945920


[10] Liebschner D, Elias M, Fournier B, Scott K, Moniot S, Guillot B, Lecomte C, Chabriere E.  “Elucidation of the phosphate binding mode of DING proteins revealed by sub-Ångstrom X-ray crystallography” (2009) JACS,131:7879-86. PMID: 19445459

[9] Darbinian N, Czernik M, Darbinyan A, Elias M, Chabriere E, Surekha Bonasu, Kamel Khalili, and Shohreh Amini, “Evidence for Phosphatase Activity of p27SJ and Its Impact on the Cell Cycle”(2009) J Cell Biol, 107:400-7. PMID: 19343785

[8] Berna A, Bernier F, Chabrière E, Elias M, Scott K and Suh A.  “For Whom the Bell Tolls?  DING Proteins in Health and Disease”(2009) Cell Mol Life Science, 66:2205-18. PMID: 19290474

[7] Pompea DV*, Elias M*, Merone L*, Graziano G, Dupuy J, Mandrich L, Carullo P, Fournier B, Rochu D, Rossi M, Masson P, Manco G, Chabriere E.“Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archeon Sulfolobus solfataricus” (2009), Extremophiles, 13:461-70. PMID: 19247785


[6] Elias M, Dupuy J, Merone L, Moniot S, Lecomte C, Rossi M, Masson P, Manco G, Chabriere E.  “Structural basis for a natural lactonase and promiscuous organophosphate hydrolysis activities” (2008), JMB, 379: 1017-28. PMID: 18486146

[5] Diemer H*, Elias M*, Renault F, Rochu D, Contreras-Martel C, Schaeffer C, Van Dorsselaer A, Chabriere E.“Tandem use of X-ray crystallography and mass spectrometry to obtain ab initio the complete and exact amino acids sequence of HPBP, a human 38kDa apolipoprotein” (2008) Proteins: Structure, Function, and Bioinformatics, 71: 1708-1720. PMID: 18076037


[4] Rochu D, Chabrière E, Renault F, Elias M, Cléry-Barraud C and Masson P. “Stabilisation of the active form(s) of human paraoxonase by human phosphate binding protein”, (2007) Biochemical Society Transactions, 35: 1616-20. PMID: 18031277

[3] Ahn S, Moniot S, Elias M, Chabriere E, Kim D, and Scott K.“Structure-Function Relationships in a Bacterial DING Protein”, (2007), FEBS letters, 581: 3455-60. PMID: 17612529

[2] Moniot S, Elias M, Kim D, Scott K and Chabriere E.“Crystallization, diffraction data collection and preliminary crystallographic analysis of DING protein from Pseudomonas fluorescens”(2007), Acta Cryst F63: 590-592. PMID: 17620718

[1] Elias M, Dupuy J, Merone L, Lecomte C, Rossi M, Masson P, Manco G, Chabriere E. “Crystallization and preliminary X-ray diffraction analysis of the hyperthermophilic Sulfolobus solfataricus phosphotriesterase” (2007), Acta Cryst. F63: 553-555. PMID: 17620708

bottom of page